Discussion
Diagnosis With Brief Discussion
- Diagnosis
- Nodular pulmonary amyloidosis
- Radiologic Findings
- Chest PA shows scattered, distributed, ill-defined, small pulmonary nodules in both lungs. Chest CT shows multiple, thin-walled, round cysts and relatively well-defined pulmonary nodules in both lungs. Some cysts contain small pulmonary nodules and some nodules contain amorphous calcifications.
- Brief Review
- Amyloidosis is a systemic disease caused by extracellular accumulation of amyloid substances. Amyloid deposition can occur in the lung in the setting of primary or secondary systemic diseases. It appears in the lung in 30%–90% of primary systemic amyloidosis cases, and secondary amyloidosis can occur with a host of chronic inflammatory diseases (e.g., collagen disease such as RA). Three histopathologic types of pulmonary amyloidosis are present: submucosal tracheobronchial deposits, diffuse interstitial deposits, and single or multiple pulmonary nodules.
Nodular amyloidosis is almost always localized to the lungs. The nodules usually are concentrated in the lower lobes and are typically subpleural or in the peripheral space. They vary in shape and size (range, 0.5–15.0 cm). Calcification or ossification is seen in up to 50% of cases. In rare instances, nodular amyloid deposits may be associated with cysts, but their relationship is unclear. Nodular amyloidosis associated with thin-walled cysts is most common in patients with Sjogren syndrome.
- Please refer to
Case 277, Case 379, Case 608, Case 786, Case 900, -
- References
- 1. Pulmonary amyloidosis with calcified nodules and masses-a six-year computed tomography follow-up: a case report Cases J 2009;2:6540
2. Nodular pulmonary amyloidosis Jpn J Thorac Cardiovasc Surg 2006;54:399–401
3. Pulmonary Amyloidosis Radiology 2012;263:929-932
- Keywords
- Lung, Metabolic and storage lung disesae,